Melanin protects the skin-;the body's largest organ and a vital component of the immune system-;from the damaging effects of ultraviolet (UV) radiation.
Tokyo University of ScienceAug 5 2024 Melanin protects the skin-;the body's largest organ and a vital component of the immune system-;from the damaging effects of ultraviolet radiation. When the skin is exposed to UV radiation, melanin production is stimulated in melanocytes, with tyrosinase playing a key role in the biosynthetic pathway. However, disruptions in this pathway caused by UV exposure or aging can lead to excess melanin accumulation, resulting in hyperpigmentation.
After screening over 100 skin-derived bacteria, the team identified C. tuberculostearicum as a producer of a potent tyrosinase-inactivating compound. Their assays utilized tyrosinase from the mushroom Agaricus bisporus to confirm inhibition. Subsequent experiments pinpointed the active compound as cyclo. The researchers then conducted three-dimensional docking simulations to elucidate how cyclo functions.
The team is highly optimistic about the potential of their discovery. Scientific literature supports the non-toxic nature of cyclo to human cells, underscoring its suitability as a skin probiotic for combating hyperpigmentation. Moreover, the metabolite exhibits additional beneficial properties such as antimicrobial, antioxidant, and anticancer activities, further enhancing its therapeutic potential across various applications.
Compound Skin Aging Hyperpigmentation Immune System Melanin Mushroom Research Vitiligo
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