Hepatocellular carcinoma (HCC) is one of the most prevalent malignancies globally and is the third leading cause of cancer-related deaths.
Xia & He Publishing Inc.Jul 16 2024 Hepatocellular carcinoma is one of the most prevalent malignancies globally and is the third leading cause of cancer-related deaths. The primary curative treatments for HCC are liver transplantation , hepatectomy, and local ablation. However, the recurrence rate of HCC following hepatectomy or ablation remains alarmingly high, up to 70%, severely impacting patient prognosis and overall survival .
HCC recurrence can generally be classified into two categories: early recurrence, which typically occurs within two years post-treatment, and late recurrence, which occurs after two years. Early recurrence is often linked to intrahepatic micrometastases or microthrombi from the primary tumor, whereas late recurrence is usually associated with multicentric new tumor formations.
The primary aim of adjuvant therapy following local treatments like hepatectomy or ablation is to reduce the recurrence rate and thus improve recurrence-free survival and OS. The choice of adjuvant therapy should be guided by the risk factors specific to early or late recurrence. Related StoriesDespite the promising results of various adjuvant therapies, there remain several unanswered questions and challenges. The lack of a universally accepted standard for adjuvant therapy in HCC highlights the need for further research and clinical trials to establish clear guidelines. Moreover, the balance between the benefits and potential adverse effects of adjuvant treatments must be carefully considered to optimize patient outcomes.
In conclusion, while significant strides have been made in the development of adjuvant therapies for HCC, ongoing research and international collaboration are essential to standardize treatment protocols and improve the prognosis for HCC patients worldwide.Journal reference:Li, L., et al. . Adjuvant Therapy for Hepatocellular Carcinoma After Curative Treatment: Several Unanswered Questions. Journal of Clinical and Translational Hepatology. doi.org/10.14218/JCTH.2024.00030.
Carcinoma Hepatocellular Carcinoma Cancer Efficacy Hepatitis Hepatology Interferon Liver Liver Transplantation Research Tenofovir Tumor
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