Most human nerve cells last a lifetime without renewal. A trait echoed within the cells' components, some enduring as long as the organism itself.
Most human nerve cells last a lifetime without renewal. A trait echoed within the cells' components, some enduring as long as the organism itself.
The latest collaborative publication by Hetzer, Tomohisa Toda from the Friedrich-Alexander University Erlangen-Nürnberg , who is also associated with the Max Planck Center for Physics and Medicine, Erlangen, and colleagues, gives new insights into this underexplored field of intricate mechanisms. For the first time in mammals, the study shows that RNA -- an essential group of molecules important for various biological processes inside the cell -- can persist throughout life.
While humans have an average life expectancy of around 70 years, the typical lifespan of a mouse is 2.5 years. After one year, the concentration of long-lived RNAs was slightly reduced compared to newborns. However, even after two years, they remained detectable indicating a lifelong persistence of these molecules.Additionally, the scientists proved long-lived RNAs' prominent role in cellular longevity.
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