Neurofilament light (NFL) is a powerful and sensitive biomarker for tracking neuronal health and disease progression.
Sponsored Content by Charles River Labs - Neuroscience Discovery ServicesReviewed by Louis CastelFeb 21 2025 insights from industryPhillip MitchellScience Director of Integrated BiologyCharles River Laboratories In this interview, industry expert Phillip Mitchell discusses the role of NfL biomarkers in CNS drug discovery , neurodegenerative disease research, treatment monitoring, neurotoxicity detection, and AI-driven biomarker selection.
One prominent example is neurofilament light , a structural protein exclusively found in neurons. NfL plays a crucial role in the stability of neuronal structures, particularly in large, myelinated axons, which rely on NfL for radial growth. Low levels of NfL are released continuously under normal conditions, but a significant increase can occur in response to axonal damage from inflammatory, neurodegenerative, traumatic, or vascular events.
In the context of neurodegenerative diseases such as Huntington’s and Alzheimer’s disease , elevated NfL levels in patient plasma and CSF serve as valuable diagnostic and prognostic indicators, correlating with disease progression and helping to distinguish between different levels of injury. Similarly, a recent study on ALS patients treated with Tofersen demonstrated significant reductions in plasma NfL levels, even though the treatment’s primary clinical endpoints were unmet. The FDA granted approval based on these biomarker changes, underscoring NfL’s role as a response marker for neurodegenerative disease treatments.
Preclinical Aging Antisense Biochemistry Blood Central Nervous System Dementia Diagnostic Drug Discovery Drugs Efficacy Global Health In Vitro Molecular Biology Muscular Atrophy Nervous System Neurodegenerative Disease Neurodegenerative Diseases Neuroimaging Neurons Neuropathy Peripheral Neuropathy Ph Positron Emission Tomography Protein Research Spinal Muscular Atrophy Structural Protein Tomography
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