A new study led by researchers at Brigham and Women's Hospital, a founding member of the Mass General Brigham healthcare system, suggests that using neurostimulation therapies on a specific brain network could treat post traumatic stress disorder (PTSD) in veterans.
Brigham and Women's Hospital Sep 24 2024 A new study led by researchers at Brigham and Women's Hospital , a founding member of the Mass General Brigham healthcare system, suggests that using neurostimulation therapies on a specific brain network could treat post traumatic stress disorder in veterans.
Siddiqi collaborated with other researchers from the Brigham's Center for Brain Circuit Therapeutics, as well as investigators from the Feinberg School of Medicine at Northwestern University, Brown University Alpert School of Medicine, and Duke University School of Medicine. He said previous studies have shown people with damage to the amygdala are less likely to get PTSD, but the team wanted to find a therapeutic target for the disease.
"One of the big gaps for developing a brain stimulation treatment for PTSD is identifying the correct therapeutic target," Fox said. The team examined 193 patients with penetrating traumatic brain injuries from the Vietnam Head Injury Study led by co-author, Jordan Grafman, PhD, at Northwestern. They looked at whether those veterans developed PTSD 20 years after the war in Vietnam.
Researchers then hypothesized that a circuit must exist that, when damaged, protects against PTSD. They used their wiring diagram, the human connectome, to map where brain damage had occurred and where each lesion connected. From there, they compared the data to 180 veterans who did not have brain damage, some of whom have PTSD and some whom do not. They found connectivity within the circuit correlated with whether they had PTSD or not.
Traumatic Brain Injury Amygdala Brain Disease Clinical Trial Cortex Depression Head Injury Healthcare Hospital Medical School Medicine Neuromodulation Neuroscience Psychiatry Research Stress Therapeutics
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