With a new $11.3 million Program Project grant from the National Institutes of Health, experts from the Vascular Biology Center at the Medical College of Georgia at Augusta University are working to better understand the underlying mechanisms of cardiovascular disease.
Medical College of Georgia at Augusta UniversityAug 8 2024
A key problem contributing to endothelial cell dysfunction is the loss of "redox balance" between harmful molecules called reactive oxygen species and helpful molecules like nitric oxide . Too much ROS and not enough NO underlies many cardiovascular diseases. To date, treatments targeting this imbalance by reducing ROS and increasing NO haven't been very effective. To develop more effective treatments, we need to understand what causes this imbalance.
To make inroads into the origins of such a prevalent and complicated problem -; approximately 83 million people have one or more forms of vascular disease in the US alone -; requires a collaborative approach. The MCG research team includes world-known endothelial and vascular biologists: Fukai; Ushio-Fukai; Eric Belin de Chantemele, PhD; David Fulton, PhD; David Stepp, PhD; and Rudolf Lucas, PhD.
Project 2 is led by Belin de Chantemele, professor of medicine and Fulton, director of the VBC, who also serves as Regents Professor of Pharmacology and Toxicology. They will study how sex-specific mechanisms involving Nox1 – a key source of ROS – and the satiety hormone, leptin, a key regulator of metabolism, impact endothelial cell metabolism and function and cardiovascular diseases such as hypertension.
Blood Blood Vessel Blood Vessels Brain Cardiovascular Disease Cell Copper Endothelial Cell Eye Glycolysis Heart Inflammation Medicine Metabolism Nutrients Oxygen Pharmacology Research Toxicology
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