The most comprehensive cell map of the human gut to date has been created by combining spatial and single-cell data from 1.6 million cells.
Wellcome Trust Sanger InstituteNov 21 2024
By having a more complete picture of the human gut in health and disease, researchers can identify any key changes or differences that could be involved in the onset of conditions such as ulcerative colitis and Crohn's disease, and lead to new possible targets for drug development. GI tract conditions impact millions of lives around the world. For example, ulcerative colitis and Crohn's disease, which are both types of IBD, affect over seven million people worldwide, with one in every 123 people in the UK living with IBD. IBD symptoms can vary between people and have a huge impact on a person's life. These include abdominal pain, diarrhoea, rectal bleeding, extreme fatigue and joint problems.
In this latest study, researchers from the Wellcome Sanger Institute and collaborators developed a new tool to harmonise these data, creating a standardised resource of gut cells that is available to researchers worldwide. This tool could also be applied to other organs, and help facilitate further studies.
By understanding more about this cycle of inflammation, it might be possible to find new ways to prevent or treat this in IBD and possibly apply this knowledge to other tissues and conditions.
Bowel Cancer Cancer Cell Colorectal Colorectal Cancer Crohn's Disease Digestive System Food Genomics Imaging Inflammation Inflammatory Bowel Disease Large Intestine Nutrients Pain Small Intestine Stomach Throat Ulcerative Colitis
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