A recent study led by UC Davis Health researchers provides new insights into the molecular changes linked to the rare genetic condition 22q11.2 deletion syndrome, or 22q.
May 1 2024University of California - Davis Health A recent study led by UC Davis Health researchers provides new insights into the molecular changes linked to the rare genetic condition 22q11.2 deletion syndrome, or 22q. It found unique biomarkers that could identify patients with 22q who may be more likely to develop schizophrenia or psychiatric conditions, including psychosis, which is commonly associated with 22q. The research was published in the journal Metabolomics .
"The molecular changes we found clearly distinguish patients with 22q from those who don't have this condition. These findings could help predict psychosis risk in these patients before symptoms manifest," said Flora Tassone, a professor in the Department of Biochemistry and Molecular Medicine. Tassone is an investigator at the UC Davis MIND Institute and the senior author of the paper. "This work could also help identify targets to aid prognosis and develop future treatments.
Participants with 22q had a follow-up visit to assess various medical conditions, including psychosis. Related StoriesSpecifically, the researchers identified two metabolites, taurine and arachidonic acid, which could serve as markers for likelihood of psychosis.
Arachidonic Acid Autism Chromosome Chromosome 22 Diagnostic Genes Heart Hyperactivity Metabolite Metabolites Metabolomics Psychosis Research Schizophrenia Syndrome Taurine
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