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A new blood test capable of identifying specific biomarkers for diseases like FTD, ALS, and PSP has been developed in Germany, offering hope for earlier diagnosis and more effective treatments for these serious neurodegenerative disorders.
Their procedure is not yet ready for routine medical use, but in the long term, it could facilitate disease diagnosis and advance the development of new therapies. The findings published in the journalFrontotemporal dementia , amyotrophic lateral sclerosis , and progressive supranuclear palsy form a spectrum of neurodegenerative diseases with overlapping symptoms characterized by dementia, behavioral symptoms, paralysis and muscle wasting, movement impairment and other serious impairments.
“We now show that PSP, a behavioral variant of FTD, and the vast majority of ALS cases with the exception of a particular mutation can be recognized by blood testing and this also applies to their underlying pathology. Our study is the first to find pathology specific biomarkers. “We have found that the combination of both markers is required for the diagnosis of behavioral FTD, respectively its subtypes, whereas TDP-43 is sufficient for ALS and the tau protein for PSP. However, for the tau marker, we are actually looking at two specific variants, so-called isoforms, of the tau protein.”. Such measurements turned out to be inconclusive, especially because tau proteins free-floating in blood are usually fragmented.
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