Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have completed the most extensive mapping of healthy breast cells to date.
Indiana University School of Medicine Aug 12 2024 Researchers at the Indiana University Melvin and Bren Simon Comprehensive Cancer Center have completed the most extensive mapping of healthy breast cells to date. These findings offer an important tool for researchers at IU and beyond to understand how breast cancer develops and the differences in breast tissue among genetic ancestries.
Breast cancer shows variability in the outcome based on your genetic ancestry. While socio-economics are certainly a contributing factor, we believe biology and ancestry also play a role. This study will help us to address that biological, ancestral aspect." Nakshatri is the Marian J. Morrison Professor of Breast Cancer Research at IU School of Medicine and a researcher of the Vera Bradley Foundation Center for Breast Cancer Research at the IU Simon Comprehensive Cancer Center.
The cell mapping includes data not only on the genes expressed in various cell types, but also on how the genes are organized and what specific gene expressions are limited to each cell type. Researchers know breast cancer most often originates in specific cell types and where it originates leads to different cancer type and treatment responses. This study could improve understanding of breast cancer development and lead to identifying new treatment targets.
Previously available research resources have used normal tissue from breast cancer surgeries and reduction mammoplasty samples. The Komen Tissue Bank, the world's only healthy breast tissue bank, offers IU researchers a unique opportunity for this study.
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