A multidisciplinary team of scientists led by Kurt Brunden, Ph.D., at the University of Pennsylvania Perelman School of Medicine, and Carlo Ballatore, Ph.D., at University of California San Diego, has been awarded a $6.
University of PennsylvaniaAug 21 2024 9 million grant from the National Institute on Aging to prepare a potential disease-modifying Alzheimer's treatment for future clinical trials. In a recently published study about the new compound, called CNDR-51997, the team found it was effective in restoring brain health in mouse models of Alzheimer's disease. CNDR-51997 was identified through a joint drug discovery program at Penn and UC San Diego that was supported by grants from the NIA.
Alzheimer's disease is characterized by abnormal deposits of two types of protein in the brain: amyloid beta and tau. The only currently available disease-modifying treatments for Alzheimer's, lecanemab and donanemab , target Aβ deposits in the brain. Notably, there are currently no approved therapies that target pathological tau. In mice, the researchers found that CNDR-51997 was able to reduce both Aβ plaques and tau pathology in the brain.
"Our findings that CNDR-51997 reduces both Aβ plaques and tau inclusions in mouse models suggest that the compound holds considerable promise for Alzheimer's disease. However, there is also a great unmet need for disease-modifying drugs for the other tauopathies," said Brunden, a research professor and director of drug discovery at Penn's Center for Neurodegenerative Disease Research.
Alzheimer's Disease Brain Compound Drug Discovery Medicine Pathology Ph Preclinical Protein Research Tau Protein
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