A recent breakthrough sheds light on how the malaria parasite, Plasmodium falciparum, invades human red blood cells. The study reveals the role of a sugar called sialic acid in this invasion process. The findings have major implications for malaria vaccine and drug development.
, invades human red blood cells. The study, led by the Swiss Tropical and Public Health Institute and Griffith University's Institute for Glycomics, reveals the role of a sugar called sialic acid in this invasion process. The findings, published yesterday inWith 249 million cases of malaria and 608,000 deaths in 2022, malaria has remained an intractable global health threat. The malaria parasiteand is responsible for the largest portion of malaria deaths.
Moreover, as the emergence of drug resistance in the parasites that cause malaria is a major health threat, the study's findings offer hope for new antimalarial drugs that are urgently needed."The essential binding activity of CyRPA to a specific glycan also validates CyRPA as drug target, and we demonstrate that small molecule inhibitors that interfered with this function can inhibit malaria replication in our study," said Jennings.Christopher J.
Lung Cancer Anemia Infectious Diseases Pests And Parasites Genetics Biology Molecular Biology
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