Irritable bowel syndrome (IBS) is a common digestive disorder that affects the intestine, causing symptoms such as abdominal pain, bloating, gas, and changes in bowel habits, including diarrhea, constipation, or both.
Tokyo University of ScienceFeb 5 2025 Irritable bowel syndrome is a common digestive disorder that affects the intestine, causing symptoms such as abdominal pain , bloating, gas, and changes in bowel habits, including diarrhea, constipation, or both. Although this condition affects about a tenth of the global population, the underlying causes and mechanisms of IBS remain unclear.
One of the main motivations for this study was the growing evidence linking IBS closely to psychological stress. Saitoh's group aimed to address this potential root cause by focusing on finding a novel animal model for this condition. In a study published in 2022, they developed a mice model repeatedly exposed to psychological stress-using a method called chronic vicarious social defeat stress -which developed symptoms similar to a type of IBS called IBS-D.
According to the results, the administration of DOP agonists helped relieve abdominal pain and regulated bowel movements in cVSDS mice. Interestingly, applying the DOP agonists directly to a specific brain region called the insular cortex had similar effects on IBS symptoms as systemic treatment.
Abdominal Pain Animal Model Bloating Central Nervous System Chronic Constipation Cortex Diarrhea Drugs Irritable Bowel Syndrome Nervous System Neuroscience Pain Pharmacology Receptor Research Stress Syndrome Technology
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