An experimental drug can supercharge the effects of the lifesaving overdose drug naloxone, potentially improving its effectiveness against new and more powerful opioids like fentanyl, a new study finds.
An experimental drug can supercharge the effects of the lifesaving overdose drug naloxone, potentially improving its effectiveness against new and more powerful opioids like) 7.6 times more effective at inhibiting the opioid response that causes overdose, researchers report in the July 3 issue of the journal“Naloxone is a lifesaver, but it's not a miracle drug; it has limitations,” said co-senior study author Susruta Majumdar, a professor of anesthesiology at Washington University in St.
The team screened a library of 4.5 million molecules, searching for molecules that could also bind to opioid receptors alongside naloxone, thus boosting its effectiveness. “The compound itself doesn't bind well without naloxone,” said lead researcher Evan O'Brien, a postdoctoral scholar at Stanford University. “We think naloxone has to bind first, and then compound 368 is able to come in and cap it in place.”
“Opioid withdrawal likely won't kill you, but they're so severe that users often resume taking opioids within a day or two to stop the symptoms. The idea that we can rescue patients from overdose with reduced withdrawal might just help a lot of people,” said co-senior researcher Jay McLaughlin, a professor of pharmacodynamics at the University of Florida.
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