Science, Space and Technology News 2024
Aficamten, an investigational drug, was found to improve oxygen usage during exercise for HCM patients in a Phase 3 trial. The study, involving Oregon Health & Science University, suggests it as a promising new treatment option.
People with a common heart condition demonstrated significantly improved oxygen utilization during exercise after taking an investigational drug, according to a study published in the. This finding was also presented at the European Society of Cardiology’s Heart Failure 2024 meeting in Lisbon, Portugal.that is evaluating the experimental drug aficamten, which was developed by Cytokinetics to treat the obstructive form of hypertrophic cardiomyopathy, or HCM.
About half of the trial’s participants were given the experimental drug, and the other half took a placebo and served as the study’s control group. Scientists measured the participants’ oxygen levels while they used treadmills or bicycles. Those who took aficamten had a significant increase in their maximum oxygen use — 1.7 milliliters per kilogram per minute more than those in the control group.
Non-drug treatment options for obstructive HCM include surgery to remove excess heart muscle. In 2022, the Food and Drug Administration alsomavacamten as the first drug designed to target the underlying cause of obstructive HCM. However, mavacamten may increase the risk of heart failure and it interacts with several commonly used medications. As a result, patients who use mavacamten must also undergo intense monitoring.
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