In 2022, nearly 619,000 global deaths due to malaria were caused by Plasmodium falciparum, the most virulent, prevalent, and deadly human malaria parasite.
University of California - RiversideSep 26 2024 In 2022, nearly 619,000 global deaths due to malaria were caused by Plasmodium falciparum, the most virulent, prevalent, and deadly human malaria parasite. For decades, the parasite's resistance to all antimalarial drugs has posed a big challenge for researchers working to stop the spread of the disease.
Disruption of the apicoplast and vesicular trafficking blocks the parasite's development and thus eliminates infection in red blood cells and in our humanized mouse model of P. falciparum malaria. We found MED6-189 was also potent against other zoonotic Plasmodium parasites, such as P. knowlesi and P. cynomolgi."
"Many of the best antimalarial agents are natural products, or are derived from them," he said. "For example, artemisinin, initially isolated from the sweet wormwood plant, and analogues thereof, are critically important for treatment of malaria. MED6-189 is a close relative of a different class of natural products, called isocyanoterpenes, that seem to target multiple pathways in P. falciparum.
Blood Compound Drugs In Vitro Medicine Mouse Model Plasmodium Falciparum Red Blood Cells Research
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