Genevieve Lane, who took Leqembi, died of a mysterious side effect called ARIA. Her death, and those of two other trial participants, have some doctors questioning whether the risks of the Alzheimer's drug are worth its benefits.
Seventy-nine-year-old Genevieve Lane volunteered to take the Alzheimer's drug Leqembi in a clinical trial because she was forgetting words and misplacing her keys. Infusions of the drug gave her headaches so severe they sent her to bed. A week after the third dose, she was at a restaurant with her best friend when her speech slurred and she had a seizure. Five days later she was dead.
usually occurs early in treatment and is usually asymptomatic, although serious and life-threatening events rarely can occur.' In a recent article, a Stanford neurologist and his colleagues detailed their concerns about , some Los Angeles medical centers are taking extra precautions. At Keck Medicine of USC, a neurologist is available 24/7 to take calls from families of those taking Leqembi, since a headache or sudden confusion can be a sign of
. The FDA “subsequently revised and updated the original advice…in a manner consistent” with the roundtable’s suggestions, wrote three of its members. 'Scientific evidence at the time led the workgroup to propose excluding people who have four or more microbleeds from clinical trials,' the association told The Times in a statement. 'The FDA agreed.
, Eisai created a website called understandingaria.com. It tells doctors that
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