A new drug strategy that regulates the tumor immune microenvironment may transform a tumor that resists immunotherapy into a susceptible one, according to a study by researchers from the Johns Hopkins Kimmel Cancer Center and Oregon Health & Science University.
Johns Hopkins MedicineNov 14 2024 A new drug strategy that regulates the tumor immune microenvironment may transform a tumor that resists immunotherapy into a susceptible one, according to a study by researchers from the Johns Hopkins Kimmel Cancer Center and Oregon Health & Science University.
In a small subset of those patients, the combination resulted in a strong response with tumor shrinkage and no disease progression for a median of 10.2 months. Additionally, laboratory analyses of patient samples taken during the trial provided insights into how the drug combination worked on the tumor microenvironment level.
Marina Baretti, M.D., lead study author, the Jiasheng Chair in Hepato-Biliary Cancer at the Kimmel Cancer Center During the trial, the team of clinical and basic researchers collected blood and tissue samples from patients. To gain a deeper understanding of the effect of entinostat on the tumor microenvironment, they performed cellular and molecular analyses, such as multiplexed immune histochemistry and whole transcriptome RNA sequencing, on the samples.
Cancer Clinical Trial Drugs Efficacy Epigenetics Genetics Immune System Immunotherapy Laboratory Lung Cancer Melanoma Oncology Pancreatic Cancer Research Tumor
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