A new drug called WNTinib can delay the growth of tumors and improve survival in hepatoblastoma, a type of liver cancer that occurs in young children.
European Organisation for Research and Treatment of Cancer Oct 22 2024 This effect was seen in cancer cells taken from patients and implanted into mice.
Ms Balaseviciute said: "The side effects of chemotherapy can have an especially large impact on children who are treated at an early age. This highlights the urgent need for new and more effective drugs that are better tolerated by paediatric patients." The researchers created three models; they implanted into mice tumour tissue taken from patients, or two cancer cell lines called HepG2 and TT001 established from patients' tumours and cultured in the laboratory. The tumours and cancer cells all had CTNNB1 mutations. The mice were treated with WNTinib and the effects were measured against untreated mice or untreated cells.
In the second model in which mice were implanted with the HepG2 cell lines, WNTinib significantly delayed tumour growth compared to the control group. On day 8, treated tumours were 30% smaller than in the control group and 46.5% smaller on day 10. The median survival for the treated mice was 16 days compared to nine days for the control group. The last mouse in the control group lived for 21 days, while , one mouse in the treatment group was still alive after 148 days.
"Overall, in all three preclinical models, we observed effective inhibition of tumour growth and a significant improvement in overall survival in hepatoblastoma with the CTNNB1 mutation. These findings suggest a promising new treatment strategy that could enhance survival in children with hepatoblastoma who carry CTNNB1 mutations. However, further studies into how WNTinib works are necessary.
Children Liver Liver Cancer Cell Cell Line Chemotherapy Cisplatin Doxorubicin Drugs Efficacy Hearing Hearing Loss Heart Hepatoblastoma Laboratory Medicine Mutation Oncology Rare Disease Research Surgery Therapeutics
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