Science, Space and Technology News 2024
Researchers developed a new epigenome editing platform that allows precise manipulation of chromatin marks, revealing their direct impact on gene expression and challenging previous understanding of gene regulation mechanisms.
Understanding how genes are regulated at the molecular level is a central challenge in modern biology. This complex mechanism is mainly driven by the interaction between proteins called transcription factors,regulatory regions, and epigenetic modifications – chemical alterations that change chromatin structure. The set of epigenetic modifications of a cell’s genome is referred to as the epigenome.
Creative depiction of the epigenetic editing toolkit: each building represents the epigenetic state of a single gene . The crane illustrates the epigenetic editing system which enables de novo deposition of chromatin marks on any genomic location. Marzia Munafò However, the causal relationship between chromatin marks and gene regulation has proved difficult to determine. The challenge lies in dissecting the individual contributions of the many complex factors involved in such regulation – chromatin marks, transcription factors, and regulatory DNA sequences.Scientists from the Hackett Group developed a modular epigenome editing system to precisely program nine biologically important chromatin marks at any desired region in the genome.
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Team develops an epigenome editing toolkit to dissect the mechanisms of gene regulationUnderstanding how genes are regulated at the molecular level is a central challenge in modern biology. This complex mechanism is mainly driven by the interaction between proteins called transcription factors, DNA regulatory regions, and epigenetic modifications—chemical alterations that change chromatin structure.
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