Patients with atrial fibrillation are typically prescribed an anticoagulant, or blood thinner, to reduce the risk of stroke, but many may discontinue them or never receive a prescription due to concerns of increased risk of bleeding complications.
Mass General BrighamJan 22 2025 Research ers from Mass General Brigham evaluated a drug that represents a new class of anticoagulants known as Factor XI inhibitors for treating patients with atrial fibrillation as part of the AZALEA-TIMI 71 Study. The trial was stopped early by the recommendation of the Data Monitoring Committee due to an overwhelming reduction in bleeding compared to standard-of-care treatment.
About 1-in-3 people will develop atrial fibrillation, making it one of the most common cardiovascular conditions in the world. The risk of stroke increases significantly in patients with atrial fibrillation because blood clots form in the heart chambers and can be pumped to the brain, causing a stroke.
The team notes that in the AZALEA-TIMI 71 Study, the rates of stroke were low and there were not any significant differences between patients in the abelacimab groups compared to those taking rivaroxaban, although the trial was not powered for ischemic events.
Bleeding Anticoagulant Blood Cardiology Healthcare Hospital Medicine Pharmaceuticals Research Rivaroxaban Stroke Therapeutics
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