Science, Space and Technology News 2024
New research has uncovered how choline, an essential nutrient, is transported into the brain by a protein called FLVCR2, crossing the blood-brain barrier. This finding is crucial for designing drugs to treat neurological disorders like Alzheimer’s and stroke. It emphasizes the importance of dietary choline and could lead to better strategies for drug delivery into the brain.
“Choline is a vitamin-like nutrient that is essential for many important functions in the body, particularly for brain development,” Dr Cater said. “We need to consume 400-500 mg of choline per day to support cell regeneration, gene expression regulation, and for sending signals between neurons.” Dr Cater was able to show that choline sits in a cavity of FLVCR2 as it travels across the blood-brain barrier and is kept in place by a cage of protein residues.
“This is critical information for understanding how to design drugs that mimic choline so that they can be transported by FLVCR2 to reach their site of action within the brain.
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