The exact origin and precursor differentiation route of tissue macrophages remains controversial. At the 2024 congress of EULAR - The European Alliance of Associations for Rheumatology - new work sheds light on blood precursors of pathogenic tissue macrophages.
Jun 13 2024European Alliance of Associations for Rheumatology , EULAR
Presenting at the 2024 EULAR congress in Vienna, Sebastien Viatte explained "we wanted to map monocyte subsets and states across studies and compartments to identify blood monocyte precursors of inflammatory synovial macrophage subsets observed in people with RA." All told, this work generated an exhaustive reference atlas comprising a total of 11 monocyte states across anatomical compartments relevant for RA. For example, it was possible to show that different clusters in fact represent the same inflammatory synovial macrophage subset, and are transcriptionally similar to an IL1B+ monocyte subset present in quiescent peripheral blood.
Autoimmune Disease Blood Cell Inflammation Joint Inflammation Macrophage Monocyte Research Rheumatoid Arthritis Rheumatology RNA RNA Sequencing
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
Reaction to England's Euro 2024 squad & Wales draw with Gibraltar, plus Euro 2024 build-upReaction to England's Euro 2024 squad announcement and Wales' draw with Gibraltar, plus build-up to England and Scotland's final warm-up matches, and all the latest football news and gossip.
Read more »
EULAR develops new classification criteria for hand osteoarthritisAt present, classifying hand osteoarthritis (OA) is based on clinical findings, and available tools are not able to distinguish between certain phenotypes.
Read more »
From Sean Baker To Selena Gomez, All The Winners From The Cannes Film Festival 2024See all the winners from the Cannes Film Festival 2024, including the winner of the Palme D’Or 2024 and Un Certain Regard 2024.
Read more »
Scotland's 10 'most dangerous' areas in 2024 named in new studyA new study has revealed the 10 'most dangerous' areas across Scotland based on their respective crime rates.
Read more »
Hands-on with F1 Manager 2024: Our first impressions of the new gameCrash.net got the fortunate opportunity to play a preview build of F1 Manager 2024. Here’s our initial impressions…
Read more »
Glasgow named 'most dangerous' area of Scotland in 2024 according to new studyAccording to a new study investigating crime rates across the country, Glasgow City is at the top of the list for 'most dangerous' in 2024 - with over 17,000 cases of dishonesty reported too.
Read more »