The study identifies links between gut microbiota, genetic variants in IBD, and mental health disorders, offering insights into potential biomarkers for CMDs.
By Dr. Sushama R. Chaphalkar, PhD.Reviewed by Lily Ramsey, LLMOct 31 2024 Study links gut microbiome diversity and genetic variants in inflammatory bowel disease patients to increased risk of mental health disorders, revealing potential biomarkers and therapeutic targets.
Background IBD, including ulcerative colitis and Crohn’s disease , involves chronic inflammation of the gut, significantly impacting quality of life. Risk factors for IBD include genetic variants, immune cytokines, gut dysbiosis, and environmental triggers. In the present study, researchers quantified gut microbial diversity, abundance, microbial quantitative trait loci , and polygenic risk scores to examine how genetic variants and gut microbiota interact to increase the risk of CMD in inflammatory bowel disease IBD patients.
Results and discussion Among IBD patients, 12.9% had significant anxiety or depression. Differences in non-psychological characteristics were minimal between CMD-affected and CMD-free patients with IBD. IBD-risk variants did not appear to influence CMD susceptibility in this cohort significantly. Furthermore, patients with CMD did not exhibit higher PRSs for anxiety or depression compared to those without CMD, suggesting a weak genetic effect of mental disorder-risk variants on CMD development in IBD patients.
Mental Health Allele Anxiety Bacteria Brain Chronic Cytokines Depression Dysbiosis Genetic Genome Genomic Hospital Inflammation Inflammatory Bowel Disease Locus Medicine Microbiome Research Ulcerative Colitis
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