The innermost layer of blood vessels is formed by endothelial cells, which in turn play a role in the development of diseases of the cardiovascular system.
University Hospital of Bonn Jul 31 2024 Human endothelial cells are therefore required for the "in vitro" investigation of the causes of these diseases. Research ers at the University Hospital Bonn and the University of Bonn have now established a highly efficient, cost-effective and reproducible way to generate functional endothelial cells from human induced pluripotent stem cells for tests in cell culture dishes.
Various differentiation strategies for hiPSCs into endothelial cells have already been developed in the past. One of the most efficient approaches to date is based on the use of different growth factors in combination with a purification step to enrich the successfully generated endothelial cells. In another approach, so-called transcription factors are specifically activated to control the conversion of hiPSCs into endothelial cells.
Stem Cells Blood Blood Pressure Blood Vessels Cell Cell Culture Hospital In Vitro Induced Pluripotent Stem Cells Physiology Transcription
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