Researchers have developed a new two-photon fluorescence microscope that captures high-speed images of neural activity at cellular resolution.
By imaging much faster and with less harm to brain tissue than traditional two-photon microscopy, the new approach could provide a clearer view of how neurons communicate in real time, leading to new insights into brain function and neurological diseases.
"By providing a tool that can observe neuronal activity in real time, our technology could be used to study the pathology of diseases at the earliest stages," said Yunyang Li, the first author of the paper."This could help researchers better understand and more effectively treat neurological diseases such as Alzheimer's, Parkinson's and epilepsy.
The researchers also developed a technique to use the DMD to mimic high-resolution point scanning. This allows a high-resolution image to be reconstructed from fast scans, providing a quick way to identify neuronal regions of interest. This is critical for the subsequent high-speed imaging with the short-line excitation and adaptive sampling scheme.
Next, the researchers are working to integrate voltage imaging capabilities into the microscope to capture a direct and extremely rapid readout of neural activity. They also plan to use the new method for real neuroscience applications, such as observing neural activity during learning and studying brain activity in disease states. Additionally, they aim to improve the microscope's user-friendliness and reduce its size to enhance its utility in neuroscience research.
Nervous System Medical Imaging Brain-Computer Interfaces Brain Injury Intelligence Medical Technology Optics Ultrasound
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