Researchers at Karolinska Institutet and Karolinska University Hospital have developed a groundbreaking microscopy method that enables detailed three-dimensional (3D) RNA analysis at cellular resolution in whole intact mouse brains.
Karolinska InstitutetNov 22 2024 Research ers at Karolinska Institutet and Karolinska University Hospital have developed a groundbreaking microscopy method that enables detailed three-dimensional RNA analysis at cellular resolution in whole intact mouse brains. The new method, called TRISCO, has the potential to transform our understanding of brain function, both in normal conditions and in disease, according to the new study published in Science.
This method is a powerful tool that can drive brain research forward. With TRISCO, we can study the complex anatomical structure of the brain in a way that was previously not possible." In the study, up to three different RNA molecules were analysed simultaneously. The next step for the researchers is to expand the number of RNA molecules that can be studied to around a hundred, using a technique called multiplex RNA analysis. This could provide even more detailed information about brain function and disease states.
Related Stories"We look forward to continuing our research and exploring the many possibilities offered by this new technique," says Shigeaki Kanatani, a research specialist in Uhlén's laboratory and the first author of the study.
Imaging RNA Hospital Laboratory Microscopy Research
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