A new model developed by Van Andel Institute, Lund University and University of Florence scientists will enable researchers to better understand how Alzheimer's disease progresses in the brain.
Like other neurodegenerative diseases, Alzheimer's is challenging to study. It is immensely complex, develops over a long period of time and varies from person to person. Critically, scientists also lack non-invasive techniques to monitor disease progression in the human brain. Instead, they often rely on models that mimic the disease, allowing them to track the ways in which Alzheimer's develops and affects the brain.
The study was published in the journal Acta Neuropathologica Communications. Lund University's Yuriy Pomeshchik, Ph.D., is co-corresponding author. Roybon was an associate professor at Lund University before joining VAI in 2022. However, studying these cells outside of the brain's microenvironment presents another challenge. Brain cells benefit from a tightly regulated ecosystem that fosters cell health and function. To solve this problem, the team used iPSCs derived from people with Alzheimer's to generate brain cells.
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