In recent years, the opioid epidemic has been worsened by the advent of street fentanyl, an illicit version of a powerful prescription painkiller.
and medical toxicology expert with Lehigh Valley Health Network-USF Morsani College of Medicine in Bethlehem, Pa. Adding to the risk, Amaducci's team further found that when a nitazene overdose occurs it's very likely to be more severe—and more difficult to treat—than an overdose attributed to fentanyl.
in the 1950s, nitazenes were ultimately never approved for medical use. In the decades since, the drugs basically fell off the radar. But nitazenes started to show up again during the early days of the pandemic, when powder, tablets and liquid versions of the opioid were first found to have filtered into the street drug supply. Since then, roughly 200 nitazene-related overdose deaths have been identified across North America and Europe, though experts caution that this could be a substantial undercount, due to a lack of adequate nitazene testing. To gain insight into the threat posed by nitazenes, Amaducci's team reviewed medical data concerning a small group of patients who were treated at anThe patients—four men and five women—ranged in age from 20 to 57. All were part of a larger group of roughly 2,300 overdose patients, of whom 537 underwent full lab testing. Just under 2% tested positive for one of a number of nitazene opioids .Overdose severity was then comparatively assessed, based on how much naloxone was needed to treat each patient., naloxone is an"opioid antagonist" that can quickly reverse and block the impact of opioids, thereby rescuing a patient whose breathing has slowed or even stopped. By that measure, said Amaducci, nitazene overdoses"seemed to be worse than heroin and fentanyl [overdoses]", because patients required significantly more doses of naloxone to reverse their overdose.
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