Therapies that deliver hydrogen sulfide to cells could one day become the basis of new treatments for obesity and related diseases, new research has concluded.
University of ExeterOct 10 2024
The new study is led by Jagiellonian University Medical College in Poland and the University of Exeter and published in Pharmacological Research. In the research, mice were fed a high-fat diet were injected with the compound AP39, which delivers hydrogen sulfide direct to mitochondria in cells The research concluded that the treatment significantly slowed the rate of weight gain, reduced by 32 per cent on average, over the 12 weeks of the study.
Study co-author Matt Whiteman, Professor of Experimental Therapeutics at the University of Exeter Medical School, first began researching the role of hydrogen sulfide in the body in 2004. He first noticed that people with type 2 diabetes who were overweight had lower levels of hydrogen sulfide in their blood. This was determined by the amount of body fat they were carrying.
Blood Compound Diabetes Diet Fatty Liver Inflammation Lipogenesis Liver Mitochondria Obesity Therapeutics
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