A new study by investigators from Mass General Brigham suggests that whether a person inherits risk of Alzheimer's disease from their mother or father influences risk of biological changes in the brain that lead to disease.
Mass General BrighamJun 18 2024 A new study by investigators from Mass General Brigham suggests that whether a person inherits risk of Alzheimer's disease from their mother or father influences risk of biological changes in the brain that lead to disease. By evaluating 4,400 cognitively unimpaired adults ages 65-85, the team found those with a history of Alzheimer's disease on either their mother's side or both parents' sides had increased amyloid in their brains.
The team examined the family history of older adults from the Anti-Amyloid Treatment in Asymptomatic Alzheimer's study, a randomized clinical trial aimed at AD prevention. Participants were asked about memory loss symptom onset of their parents. Researchers also asked if their parents were ever formally diagnosed or if there was autopsy confirmation of Alzheimer's disease.
"If your father had early onset symptoms, that is associated with elevated levels in the offspring," said Mabel Seto, PhD, first author and a postdoctoral research fellow in the Department of Neurology at the Brigham. "However, it doesn't matter when your mother started developing symptoms -; if she did at all, it's associated with elevated amyloid."
"It is also important to note a majority of these participants are non-Hispanic white," Seto added. "We might not see the same effect in other races and ethnicities."
Biomarker Brain Clinical Trial Genomics Hospital Imaging Neurology Research
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