Nearly half the world's population lives in regions where malaria is endemic, with the parasite Plasmodium falciparum accounting for approximately 95% of malaria-related deaths globally.
University of California - RiversideDec 20 2024 Nearly half the world's population lives in regions where malaria is endemic, with the parasite Plasmodium falciparum accounting for approximately 95% of malaria-related deaths globally. Now, a new research project funded by the National Institutes of Health and led by a malaria expert at the University of California, Riverside aims to uncover the molecular factors that govern gene regulation and chromatin organization in P.
"Malaria is one of the deadliest infectious diseases worldwide and understanding the underlying molecular mechanisms that drive the severity of P. falciparum infections is critical to developing effective therapies," said Karine Le Roch, a professor of molecular, cell and systems biology and the principal investigator of the five-year grant of nearly $4 million.
We want to identify how lncRNAs contribute to the survival and transmission of P. falciparum, and whether targeting these molecules could lead to novel therapeutic strategies. If successful, our work could provide new avenues for drug development, offering hope for more effective treatments or vaccines to fight malaria.
Cell Chromatin DNA Gene Plasmodium Falciparum Research Research Project RNA
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