Cytotoxic T-lymphocyte antigen 4 (CTLA-4) is a protein receptor on T immune cells that prevents the cells from killing other cells, such as cancer cells.
WileyAug 7 2024 Cytotoxic T-lymphocyte antigen 4 is a protein receptor on T immune cells that prevents the cells from killing other cells, such as cancer cells. Blocking CTLA-4 with a specific antibody is an effective treatment for some cancers, but it can damage the heart. New research published in The FASEB Journal reveals the mechanisms involved in this side effect-;a finding that could be used to help prevent it.
Experiments conducted in mice showed that blocking CTLA-4 activates certain T cells called Th17 cells, which increase inflammation. Inhibiting this activation reversed anti-CTLA-4–mediated heart damage. "Targeting this axis could potentially offer a preventive or therapeutic strategy for managing cardiotoxicity in patients undergoing anti-CTLA-4-based immune checkpoint inhibitor therapy," the authors wrote.Journal reference:Shang, A-Q., et al. Blocking CTLA-4 promotes pressure overload-induced heart failure via activating Th17 cells. FASEB Journal. doi.org/10.1096/fj.202400384R.
Heart Antibody Antigen CTLA-4 Lymphocyte Protein Receptor Research
United Kingdom Latest News, United Kingdom Headlines
Similar News:You can also read news stories similar to this one that we have collected from other news sources.
How an effective cancer therapy may damage the heartCytotoxic T-lymphocyte antigen 4 (CTLA-4) is a protein receptor on T immune cells that prevents the cells from killing other cells, such as cancer cells. Blocking CTLA-4 with a specific antibody is an effective treatment for some cancers, but it can damage the heart.
Read more »
Cytotoxic properties of cyclophosphamide: A focus on its mechanistic impacts on male gonadal functionsCyclophosphamide (CP), a widely used chemotherapeutic and immunosuppressive agent, has significant impacts on reproductive health in both males and females.
Read more »
After devastating floods and ten years of work, gymnastics gym relaunchesThe experience for our gymnasts and coaches has been improved with new convenient access, new toilets, new locker areas, new offices and new reception areas
Read more »
New England Patriots hopes of finally having Tom Brady successor boosted as incredible Drake Maye footage...New England Patriots may have the new Tom Brady as incredible Drake Maye footage emerges
Read more »
New images released as updated plans outlined for new Stockport neighbourhoodThe huge scheme has moved one step closer with another public consultation launched
Read more »
The SNP need new policies and new faces to target LabourCHANGE. That word got Scottish Labour MPs elected big style last week...
Read more »