Gamma delta (γδ) T cells are a type of unique innate T lymphocyte that are considered to be among the best candidate cells for use in immunotherapy. However, owing to their rarity in the peripheral circulation and lymphoid organs, their precise role in regulating antitumor immune response remains more or less unclear.
Recent advances in tumor immunotherapy have, however, increased the focus of research on γδ T cells. Of particular interest is their strong cytotoxicity against a variety of tumor cells without major histocompatibility complex restriction.Chinese Medical JournalThe basic research andenlisted in this review strives to provide a theoretical basis for the development of γδ T cell-based clinical interventions in the near future.
In this review now, the authors report that multiple research groups have identified various hidden γδ T mechanisms in 2022. For instance, a landmarkstudy found that when mouse skin was exposed to common forms of stress , γδ T cells were able to detect changes in the cellular environment and help the skin recover.Nature
Speaking about the research advances further, senior author Hui Chen, affiliated with the Changzhou Xitaihu Institute for Frontier Technology of Cell Therapy and Peking Union Medical College, says,"Tumor-infiltrating γδ T cells have been shown to be the immune cells that are most positively associated with patient survival in all cancers.
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