The rapid influx of cerebral spinal fluid (CSF) and protein solutes released during cortical spreading depression (CSD) in the brain activates neurons to trigger aural migraine headaches, according to a new mouse study.
American Association for the Advancement of Science Jul 4 2024 The rapid influx of cerebral spinal fluid and protein solutes released during cortical spreading depression in the brain activates neurons to trigger aural migraine headaches, according to a new mouse study. The findings identify a novel non-synaptic signaling mechanism between the brain and peripheral sensory system important for migraine. They also suggest potential pharmacological targets for treating the painful disorder.
Migraine with aura, or an aural migraine, is a distinct headache disorder that can include sensory disturbances, such as hearing- or vision-related symptoms that precede onset of headache pain. During the aura phase, it is believed that waves of CSD are spontaneously triggered in the cerebral cortex or cerebellum, which, in turn, lead to activation of pain receptors in the peripheral nervous system .
Rasmussen et al. found that CSD alters 11% of the CSF proteome, with up-regulation of proteins that directly activate receptors in the trigeminal ganglion, including calcitonin gene-related peptide .
Migraine Nerve Pain Cortex Depression Ganglion Headache Nervous System Neurons Protein
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