FELIX study results reveal obe-cel's potential in relapsed B-cell ALL, achieving 77% remission with low severe toxicity, enhancing CAR T-cell therapy outcomes.
By Vijay Kumar MalesuReviewed by Danielle Ellis, B.Sc.Dec 2 2024 Phase 1b–2 trial evaluates the potential of CAR T-cell therapy obe-cel in relapsed or refractory B-cell ALL patients.
Early trials in pediatric and adult populations demonstrated high efficacy, durable responses, and low severe toxicity rates. Further research is needed to optimize treatment protocols, improve long-term outcomes, and expand accessibility for diverse patient populations. Patients underwent leukapheresis to manufacture obe-cel. They received a bone marrow burden-adjusted split dose after lymphodepletion , with dosing guided by pre-treatment bone marrow assessments. Bridging therapy was allowed, excluding blinatumomab.
Related StoriesBridging therapy was administered to 92.9% of infused patients, with chemotherapy being the most common approach. Bone marrow assessments before lymphodepletion indicated a high disease burden in many patients, with 59% having more than 20% bone marrow blasts. Patients with high blast burdens typically required more intensive bridging therapy. A bone marrow burden–adjusted split-dose regimen of obe-cel was implemented, and 94.5% of patients received the full planned doses.
Acute Lymphoblastic Leukemia Antigen Blood Bone Bone Marrow Cancer CAR T-Cell Cell Chimeric Antigen Receptor Efficacy Manufacturing Medicine Receptor Syndrome T-Cell
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