A recent study published in Menopause, the journal of The Menopause Society, analyzed data from over 75,000 women and found no significant association between hormone therapy (HT) use and the risk of developing gliomas, a common type of brain tumor. This research provides valuable insight into the ongoing debate surrounding the risks and benefits of HT, particularly in relation to brain health.
The prevalence of debilitating conditions among women, such as osteoporosis, migraines, Alzheimer's disease, depression, multiple sclerosis, and brain tumors , has long been a subject of concern. While sex hormones are often cited as a contributing factor, a recent study published in Menopause , the journal of The Menopause Society, suggests otherwise.
This research, which analyzed data from over 75,000 women with a median follow-up period of nearly 12 years, found no significant association between hormone therapy (HT) use and the risk of developing gliomas, a common type of brain malignancy.The debate surrounding the risks and benefits of HT has raged for over two decades. Key concerns center around potential effects on brain and breast health, as well as cancer risks, which must be weighed against the proven benefits of hormones in alleviating common menopause symptoms like hot flashes, mood swings, and vaginal dryness. Glioma, a type of brain cancer with limited effective treatments and a significant sex disparity (roughly 6:1), has been speculated to be influenced by both exogenous and endogenous sex hormones. Previous smaller studies on the link between HT and glioma risk have yielded inconsistent results. However, this large-scale study, drawing on data from the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, sheds new light on the matter.The study's findings indicate that while there is a known sex difference in the incidence of gliomas, with women being six times more likely to develop the disease compared to men, there is no apparent association between glioma and hormone therapy use in postmenopausal women. While these findings are promising, Dr. Stephanie Faubion, Medical Director of The Menopause Society, emphasizes the need for larger prospective studies with longer follow-up periods to definitively confirm these results
Hormone Therapy Brain Tumors Glioma Menopause Women's Health
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