A study in eBioMedicine uncovers two genetic loci that modify the impact of fiber and fruit intake on colorectal cancer risk, highlighting gene-diet interactions.
By Dr. Sushama R. Chaphalkar, PhD.May 22 2024Reviewed by Susha Cheriyedath, M.Sc. In a recent study published in the journal eBioMedicine, researchers performed a genome-wide interaction analysis to investigate whether genetic variants potentially modify the association between fiber, fruit, and vegetable intake and the risk of colorectal cancer . They successfully identified two significant loci that modify the association of fiber and fruit intake with CRC risk.
Previous genome-wide association studies could identify at least 200 loci linked to CRC risk, accounting for up to 35% of heritability. Although gene-environment interactions could potentially explain additional heritability, prior studies with small sample sizes and traditional methods found only limited significant gene-diet interactions.
Results and discussion As compared to controls, participants with CRC were found to be older, had a higher body mass index and energy intake, and had a greater prevalence of risk factors like a family history of CRC and type 2 diabetes. They were also found to consume less fiber, fruits, and vegetables compared to controls. Meta-analyses revealed inverse associations between the intake of fiber =0.79), fruits , and vegetables and CRC risk.
Genes Allele Anatomy Colorectal Colorectal Cancer Diet Frequency Fruit Gene Genetic Genome Locus Quality Control Vegetables
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