Every living cell transcribes DNA into RNA. This process begins when an enzyme called RNA polymerase (RNAP) clamps onto DNA.
Rockefeller UniversityJul 3 2024 Every living cell transcribes DNA into RNA . This process begins when an enzyme called RNA polymerase clamps onto DNA . Within a few hundred milliseconds, the DNA double helix unwinds to form a node known as the transcription bubble, so that one exposed DNA strand can be copied into a complementary RNA strand.
This is the first time anybody has been able to capture transient transcription complexes as they form in real time. Understanding this process is crucial, as it is a major regulatory step in gene expression." An unprecedented view Darst was the first to describe the structure of bacterial RNAP, and teasing out its finer points has remained a major focus of his lab.
Related StoriesFor the first time, a clear picture of the structural changes and intermediates that form during the initial stages of RNA polymerase binding to DNA snapped into focus. "The technology was extremely important to this experiment," Saecker says. "Without the ability to mix DNA and RNAP quickly and capture an image of it in real-time, these results don't exist."
Transcription Cell DNA E. Coli Electron Electron Microscopy Enzyme Helix Laboratory Microscopy Molecular Biology Polymerase Protein Research RNA Technology
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