A study using 7T QSM identifies microstructural changes in the brainstem of COVID-19 survivors, suggesting links to long-term neuroinflammatory responses.
By Tarun Sai LomteReviewed by Lily Ramsey, LLMOct 10 2024 Groundbreaking MRI study links brainstem damage to long COVID symptoms in survivors.
These brainstem abnormalities have been proposed as a mechanism for post-acute COVID-19 syndrome . Nevertheless, conventional 3 Tesla magnetic resonance imaging has not shown consistent brainstem abnormalities at follow-up. As such, advanced MRI techniques, e.g., QSM, have the potential to identify more subtle changes.
The lowest platelet levels and the peak D-dimer and C-reactive protein levels during hospitalization were recorded. Findings Overall, 30 COVID-19 patients and 51 HCs were enrolled. The two groups did not significantly differ in age; however, the control group had more males than females. Additional clusters were identified in the midbrain and pons at a less stringent threshold. The mean susceptibility values extracted from the two medullary clusters were positively associated with the peak CRP detected during hospitalization and weakly associated with clinical disease severity and length of hospital stay. No significant trends were observed for other variables.
Covid-19 Brain Chronic Coronavirus Encephalopathy Hospital Imaging Inflammation Magnetic Resonance Imaging Multiple Sclerosis Neurodegeneration Respiratory Sclerosis Syndrome
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