New study sheds light on irregular heartbeat risk

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New study sheds light on irregular heartbeat risk
HeartResearchArrhythmia
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Two new, basic animal research studies shed light on alcohol consumption and the heart. The first study may help explain why binge drinking sometimes causes an irregular heartbeat and a possible way to prevent it. The second study investigated why alcohol may have a negative impact on heart function in women taking estrogen replacement therapy.

American Heart AssociationJul 23 2024 Both studies are preliminary research on posters presented at the American Heart Association's Basic Cardiovascular Sciences Scientific Sessions 2024. The meeting is in Chicago, July 22–25, 2024, and offers the latest research on innovations and discovery in cardiovascular science.

"Repeated binge drinking can lead to serious arrhythmias. This includes AFib, which is the most common type of arrhythmia." Said Khanal. Previous animal research by this research team found binge-drinking-related arrhythmias are induced by elevations in a stress-induced protein called JNK2. This can cause heart cells to mishandle calcium and misfire, resulting in the heart beating too fast or irregularly. The new study suggests, for the first time, that the molecule Alda-1 may prevent the activation of JNK2 that leads to AFib."Abstinence from alcohol can prevent most alcohol-associated AFib risks.

The hormone estrogen helps keep blood vessels open and flexible and is generally thought to help protect women from heart disease. These higher estrogen levels may lead to fewer heart attacks and strokes in premenopausal women than in men of the same age. However, alcohol exposure worsens cardiovascular function more in women than men, researchers said. Also, in previous animal studies, alcohol has been confirmed to worsen heart function more in those animals with the highest estrogen levels.

The study found that, compared to those receiving alcohol alone, the menopausal rats treated with estrogen replacement plus alcohol had:

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Heart Research Arrhythmia Atrial Fibrillation Binge Drinking Blood Blood Pressure Calcium Cell CT Diet Estrogen Ethanol Ferroptosis Heart Failure Hormone Hospital Medicine Menopause Molecule Mouse Model Ovaries Oxidative Stress Ph Protein Stress Syndrome

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