A team of cancer researchers, led by the University of Houston, has discovered a new subset of T cells that may improve the outcome for patients treated with T-cell therapies.
May 28 2024University of Houston
While T-cell immunotherapy has revolutionized cancer treatment, there is still much to learn. Unfortunately, not all patients respond to these therapies, so a better understanding of the properties of engineered T cells is necessary to improve clinical responses. "Our results showed that a subset of T cells, labeled as CD8-fit T cells, are capable of high motility and serial killing, found uniquely in patients with clinical response," reports first author and recent UH graduate Ali Rezvan in Nature Cancer.
Chimeric antigen receptors T cells used for the treatment of B cell malignancies can identify T-cell subsets with superior clinical activity. Using infusion products of patients with large B cell lymphoma, we integrated functional profiling using TIMING with subcellular profiling and scRNA-seq to identify a signature of multifunctional CD8 T cells .
B Cell Cancer Treatment Cell Drugs Immune System Immunotherapy Lymphoma RNA RNA Sequencing T-Cell
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