Researchers have found a protein to block the growth of cancer stem-like cells as a possible treatment for pancreatic cancer.
The dismal prognosis ofis linked to the presence of a cell population called cancer stem-like cells . These have been shown to increase resistance to chemotherapy, so annihilating CSCs has emerged as an essential aim of pancreatic cancer treatment. But the underlying processes driving CSCs are insufficiently understood.
Led by Siim Pauklin, CRUK Career Development Fellow at NDORMS, the team hypothesized that epigenic proteins are essential to maintain the resistive properties of CSCs. They started to look for targets and identified the protein BRD9 as a regulator of CSC behavior making it an attractive therapeutic target for specifically eliminating CSCs in pancreatic cancer.
"We started looking for potential targets that regulate stem cell-like characteristics of CSCs," said Siim."Through awe identified the protein BRD9 and discovered that inhibition of this protein significantly reduced CSCs self-renewal, invasiveness, and resistance to chemotherapy. This discovery could open up new opportunities for the treatment of pancreatic cancer.
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