Researchers have found a way to program immune cells to attack glioblastoma and treat the inflammation of multiple sclerosis in mice.
University of California San FranciscoDec 6 2024 The technology will soon be tested in a clinical trial for people with glioblastoma.
The scientists showed how the immune cells could eliminate a deadly brain tumor called glioblastoma and prevent recurrences. They also used the cells to tamp down inflammation in a mouse model of multiple sclerosis. Brain cancers are among the hardest cancers to treat. Surgery and chemotherapy are risky, and drugs can't always get into the brain.
The scientists programmed the immune cells to attack only if they first detected brevican and then detected one or the other of the brain cancer proteins. The brain-primed CAR-T cells were very, very effective at clearing glioblastoma in our mouse models, the most effective intervention we've seen yet in the lab. It shows just how well the GPS ensured that they would only work in the brain. The same strategy even worked to clear brain metastases of breast cancer." In another experiment, the researchers used the brain GPS system to engineer cells that deliver anti-inflammatory molecules to the brain in a mouse model of multiple sclerosis.
Brain Metastases Brain Tumor Cancer Cell Clinical Trial Glioblastoma Inflammation Living Cells Mouse Model Multiple Sclerosis Protein Sclerosis Technology Tumor
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