In an animal model of Duchenne muscular dystrophy, Brazilian researchers tested a therapy that combines photobiomodulation using laser light or light-emitting diodes (LEDs) with idebenone, an antioxidant compound investigated for application in neurodegenerative diseases.
São Paulo Research FoundationJun 14 2024 In an animal model of Duchenne muscular dystrophy, Brazilian researchers tested a therapy that combines photobiomodulation using laser light or light-emitting diodes with idebenone, an antioxidant compound investigated for application in neurodegenerative diseases .
Duchenne is caused by mutations in the gene that encodes dystrophin, a protein essential to muscle function. In skeletal muscle, dystrophin acts as a cytoskeletal stabilization protein and protects cells against contraction-induced damage. When dystrophin is absent or reduced, muscles cannot repair themselves or function properly. In Duchenne, contractile tissue is gradually replaced by fatty fibrotic connective tissue, causing inflammation and muscle wasting.
"For these reasons, our research group has been focusing on studies of muscle fiber biology in dystrophin-deficient mice to seek novel therapies with the potential to minimize progression of the disease and improve the dystrophic patient's quality of life," said Professor Elaine Minatel, Vice Head of the Department of Structural and Functional Biology at the State University of Campinas's Institute of Biology .
Related StoriesIn light of the action mechanisms involved, the research group set out to see whether their combined use had a potential therapeutic effect on the muscle fibers of dystrophin-deficient patients by means of in vitro and in vivo experiments with mice.
Muscular Dystrophy Animal Model Antioxidant Compound Dystrophin Education Gene Genetic Genetic Disorder In Vitro In Vivo Inflammation LED Therapy Muscle Muscle Wasting Neurodegenerative Diseases Protein Research
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