The development of molecules to study and treat disease is becoming increasingly burdened by the time and specificity required to analyze the vast amounts of data generated by synthesizing large collections of new molecules.
St. Jude Children 's Research Hospital Dec 12 2024 Scientists at St. Jude Children 's Research Hospital present a novel solution to this problem, using the fundamental fragmentation patterns of chemical building blocks to barcode reactions from starting materials to products. In doing so, they have removed a key bottleneck in the process of synthesizing and screening small molecules . The work was published today in Nature.
"Generality is essential for doing anything quickly. So, we sought to identify general features which would uniformly encode the analysis of small molecules," explained Blair, corresponding author of the Nature article. "Because these fragmentation patterns are a fundamental property of chemical matter, they are reliably transposable from starting materials to products. As soon as you recognize that starting materials can define the analysis of the resulting chemical products, you've generalized the entire approach," said first author Maowei Hu, PhD, St. Jude Department of Chemical Biology and Therapeutics.
Cell Chemical Reaction Children Hospital Research Small Molecules Therapeutics
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