The association between platelet hyperreactivity and the risk of cardiovascular events.
By Dr. Sushama R. Chaphalkar, PhD.Reviewed by Lily Ramsey, LLMAug 22 2024 In a recent study published in Nature Communications, researchers from the United States of America investigated the association between platelet hyperreactivity and the risk of cardiovascular events.
Background Platelets are crucial in atherogenesis and thrombosis, and increased platelet activity is linked to higher long-term mortality and cardiovascular events. Despite advancements in our understanding of platelet biology through transcriptome analyses, routine clinical assessment of platelet aggregation remains challenging.
About 54% of the patients had coronary artery disease, 53% had diabetes, and 78% had critical limb ischemia. The patients were followed for 30 days to monitor cardiovascular events using electrocardiograms , blood tests, and follow-up calls. The study also explored the gene expression differences between groups. It validated PRESS across multiple conditions, including lower extremity atherosclerosis , systemic lupus erythematosus , coronavirus disease 2019 , and acute myocardial infarction .
Further, hyperreactive platelets were found to be linked to a nearly threefold increased risk of MACLE. The addition of platelet hyperreactivity to the Revised Cardiac Risk Index was shown to improve the prediction for MACLE.
Diabetes Epinephrine Gene Gene Expression Mortality Peripheral Artery Disease Phenotype Platelet Platelets Thrombosis
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