Researchers at the Bellvitge Biomedical Research Institute (IDIBELL), the Germans Trias i Pujol Research Institute (IGTP), and other institutions have identified a potential new treatment for malignant peripheral nerve sheath tumor (MPNST), an aggressive sarcoma with a high tendency to metastasize. The findings, published in Clinical Cancer Research, show promising results in preclinical models using patient-derived xenografts (PDX) and cell lines. The new treatment combines three different types of inhibitors targeting specific genes frequently mutated in MPNSTs.
Germans Trias i Pujol Research InstituteJan 28 2025 A multicenter collaboration led by the Bellvitge Biomedical Research Institute - Institut Català d'Oncologia and the Germans Trias i Pujol Research Institute identified a potential new treatment for an aggressive sarcoma arising in the nerves. The findings have been published in the journal Clinical Cancer Research.
A valuable resource: A pre-clinical platform for precision medicine Currently, there is a lack of an effective therapy for MPNSTs beyond a timely surgery, since conventional radio or chemotherapy do not show very good responses.
All models and primary tumors have been genomically characterised and compared, enabling their use in precision medicine strategies, where drugs are tailored to treat tumors based on specific mutations identified in each case. Over time, this resource has grown significantly, now comprising many different MPNST models, and serving as a foundation for drug screening to predict treatment responses.
From drug screening to the clinics: research with impact In a first step, researchers took advantage of a fruitful collaboration with Dr Marc Ferrer, at the National Center for Advancing Translational Sciences at NIH , and used robotics to screen hundreds of combinations of different inhibitors of each class: MEKi, to target the loss of NF1, CDKi to target the loss of CDKN2A and BETi to target the loss of PRC2 function.
SARCOMA CANCER TREATMENT MPNST PRECISION MEDICINE GENETIC MUTATIONS
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