Stephanie Pappas is a contributing writer for Live Science, covering topics ranging from geoscience to archaeology to the human brain and behavior.
A new treatment for human immunodeficiency virus can drive the virus out of its hiding spots in the body, an early clinical trial finds. That, in turn, raises hopes these reservoirs of HIV could then be wiped out.
"Clearly we need better tools, better drugs, better approaches," he said,"but it does suggest that this strategy itself is deserving of more work."HIV in hidingWith modern antiretroviral drugs, doctors can prevent HIV from spreading from cell-to-cell inside the body, allowing people with the infection to live normal lives. Many achieve undetectable viral loads, meaning they cannot transmit HIV to others via sex.
By submitting your information you agree to the Terms & Conditions and Privacy Policy and are aged 16 or over.To truly cure the infection, the latent HIV reservoir must be driven out and destroyed. That's challenging, though, said Edward Browne, a professor of medicine at UNC's School of Medicine who has previously collaborated with Margolis but was not involved in the recent trial.
Margolis and his team attempted this with vorinostat, a drug shown to"wake up" HIV from latency in many previous studies. To attack the activated virus, they took patients' own immune cells, identified those programmed to attack HIV, and then grew these cells and reinfused them into the patients.
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