New understanding of how antidepressants work

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New understanding of how antidepressants work
Psychology ResearchMental Health ResearchWorkplace Health
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Researchers have established a new framework for understanding how classic antidepressants work in treating major depressive disorder (MDD), reemphasizing their importance and aiming to reframe clinical conversation around their role in treatment.

Researchers have established a new framework for understanding how classic antidepressants work in treating major depressive disorder , reemphasizing their importance and aiming to reframe clinical conversation around their role in treatment.

Antidepressants, such as SSRIs and serotonin and norepinephrine reuptake inhibitors are still effective in alleviating depressive episodes in many patients, however. In a paper published in, researchers outline a new framework for understanding how antidepressants are efficacious in treating MDD. This framework helps clarify how antidepressants like SSRIs are still be helpful, even if MDD isn't caused by a lack of serotonin.

Thompson and colleagues liken this theory to a car running off the road and getting stuck in a ditch, requiring the help of a tow truck to pull the car out of its stuck state, allowing it to move freely down the road again.

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